pyridoxal kinase, pyridoxine kinase (PDXK, pyridoxamine kinase)

Function

• synthesis of pyridoxal-5-phosphate from vitamin B6

ATP + pyridoxal -> ADP + pyridoxal-5-phsophate

Cofactor:

• divalent cations
• Zn+2 is more efficient than Mg+2

Optimum pH is 5.5-6.0

Structure

• homodimer (probable)
• belongs to the pyridoxine kinase family

Compartment

cytoplasm

Alternative splicing

named isoforms=3

Expression

• ubiquitous
• isoform 3 is detected in adult testis & spermatozoa

More general terms

• kinase or ATP-phosphotransferase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8566
• OMIM: https://mirror.omim.org/entry/179020
• UniProt: http://www.uniprot.org/uniprot/O00764.html