N-acylneuraminate cytidylyltransferase (CMP-N-acetylneuraminic acid synthetase, CMP-NeuNAc synthetase, CMAS)
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Function
- catalyzes activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid
- sialic acid metabolism
- homotetramer, active enzyme is formed by a dimer of dimers
Compartment
Alternative splicing
named isoforms=2
Expression
- ubiquitously expressed
- expressed in pancreas, kidney, liver, skeletal muscle, lung, placenta, brain, heart, colon, PBL, small intestine, ovary, testis, prostate, thymus, spleen