alanine aminotransferase 1 (ALT1, glutamic-pyruvic transaminase 1, GPT 1, glutamic-alanine transaminase 1, GPT1, AAT1)

Function

• role in cellular nitrogen metabolism
• role in liver gluconeogenesis starting with precursors transported from skeletal muscles
• induced by glucocorticoids

L-alanine + 2-oxoglutarate <--> pyruvate + L-glutamate

Cofactor: pyridoxal phosphate

Structure

homodimer

Compartment

• two isozymes; one cytoplasmic, one mitochondrial

Expression

• expressed in liver, kidney, heart, skeletal muscles, adipose tissue

More general terms

• alanine aminotransferase

Database

• UniProt: http://www.uniprot.org/uniprot/P24298.html
• OMIM: https://mirror.omim.org/entry/138200