diamine acetyltransferase 2; polyamine N-acetyltransferase 2; spermidine/spermine N(1)-acetyltransferase 2; thialysine N-epsilon-acetyltransferase (SAT2, SSAT2)

Function

• catalyzes acetylation of polyamines
• substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.

Acetyl-CoA + alkane-alpha,omega-diamine
         <-->
CoA + N-acetyldiamine

Structure

• belongs to the acetyltransferase family
• contains 1 N-acetyltransferase domain

Compartment

intracellular organelles

Expression

• widely expressed
• not inducible by polyamine analogs
• SSAT2 expressed at lower level than SSAT1
• any tissues express only SSAT1
• several tissues express both SSAT1 & SSAT2
• bone, cervix, ovary, pineal gland express only SSAT2

More general terms

• acetyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=112483
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:112483
• OMIM: https://mirror.omim.org/entry/611463
• UniProt: http://www.uniprot.org/uniprot/Q96F10.html