carboxylesterase 2; CE-2; hCE-2; (CES2, ICE)

Function

• role in the detoxification of xenobiotics & in the activation of ester & amide prodrugs
• high catalytic efficiency for hydrolysis of 4-methyumbelliferyl acetate, heroin & 6-monoacetylmorphine

Structure

• monomer
• glycosylated
• belongs to the type-B carboxylesterase/lipase family

Compartment

endoplasmic reticulum lumen (putative)

Alternative splicing

named isoforms=2

Expression

• preferentially expressed in intestine
• moderate expression in liver
• within the intestine, highest expression is found in small intestine with lower expression in colon & rectum

More general terms

• carboxylase (carboxylic ester hydrolase)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8824
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8824
• OMIM: https://mirror.omim.org/entry/605278
• UniProt: http://www.uniprot.org/uniprot/O00748.html