aldo-keto reductase family 7, member A3; aflatoxin B1 aldehyde reductase 2; AFB1-AR 2 (AKR7A3, AFAR2)

Function

• can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol
• may be involved in protection of liver against the toxic & carcinogenic effects of AFB1, a potent hepatocarcinogen (putative)

Structure

• probably act as a homodimer (putative)
• belongs to the aldo/keto reductase 2 family

Compartment

cytoplasm

Expression

• expressed in colon, kidney, pancreas, adenocarcinoma & endometrium

More general terms

• aldo-keto reductase

Database

• UniProt: http://www.uniprot.org/uniprot/O95154.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2297
• OMIM: https://mirror.omim.org/entry/608477
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22977