6-phosphogluconate dehydrogenase (PGD, PGDH, 6PGD)

Function

• carbohydrate degradation; pentose phosphate pathway;
• D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3

6-phospho-D-gluconate + NADP+
            <-->
D-ribulose 5-phosphate + CO2 + NADPH

Structure

• homodimer (putative)
• belongs to the 6-phosphogluconate dehydrogenase family

Pathology

• defects associated with 6-phosphogluconate dehydrogenase deficiency

More general terms

• carbohydrate dehydrogenase

Additional terms

• hexose monophosphate shunt, pentose phosphate pathway or phosphogluconate shunt

Database

• OMIM: https://mirror.omim.org/entry/172200
• UniProt: http://www.uniprot.org/uniprot/P52209.html