alcohol dehydrogenase-4 (alcohol dehydrogenase class 2 pi chain, ADH4)

Function

• degrades circulating epinephrine & norepinephrine
• may account for 40% of ETOH degradation at intoxicating levels
• ADH-2 does not degrade ethylene glycol

an alcohol + NAD+ <--> an aldehyde or ketone + NADH

Cofactor: binds 2 Zn+2 per subunit (putative)

Structure

• homodimer
• belongs to the Zn+2-containing alcohol dehydrogenase family, class-2 subfamily

Compartment

cytoplasm

Polymorphism

• ADH2*2 may be protective for heavy drinking & alcoholism

More general terms

• alcohol dehydrogenase (aldehyde reductase)

Database

• UniProt: http://www.uniprot.org/uniprot/P08319.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:127
• OMIM: https://mirror.omim.org/entry/103740
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=127