glycerol-3-phosphate dehydrogenase, mitochondrial; GPDH-M; GPD-M; mtGPD (GPD2)

Function

• Ca+2-binding enhance activity of the enzyme
• polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1

sn-glycerol 3-phosphate + acceptor
          <-->
glycerone phosphate + reduced acceptor

Cofactor: FAD

Structure

• belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
• contains 2 EF-hand domains

Compartment

mitochondria

Alternative splicing

named isoforms=2

More general terms

• glycerol-3-phosphate dehydrogenase
• phosphoprotein
• Ca+2 binding protein
• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/P43304.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2820
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2820
• OMIM: https://mirror.omim.org/entry/138430