claudin-18 (CLDN18)

Function

• plays a major role in tight junction-specific obliteration of the intercellular space, through Ca+2-independent cell-adhesion activity (putative)

Structure

• belongs to the claudin family

Compartment

• cell junction, tight junction
• cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2; A1, A2

Expression

• concentrated at the cell-cell borders of epithelial cells

More general terms

• claudin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51208
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51208
• OMIM: https://mirror.omim.org/entry/609210
• UniProt: http://www.uniprot.org/uniprot/P56856.html