claudin-14 (CLDN14)

Function

• plays a major role in tight junction-specific obliteration of the intercellular space, through Ca+2-independent cell-adhesion activity (putative)

Structure

• belongs to the claudin family

Compartment

• cell junction, tight junction
• cell membrane; multi-pass membrane protein

Expression

• liver, kidney. also found in ear

Pathology

• defects in CLDN14 are the cause of deafness autosomal recessive type 29

More general terms

• claudin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23562
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23562
• OMIM: https://mirror.omim.org/entry/605608
• UniProt: http://www.uniprot.org/uniprot/O95500.html