tripartite motif-containing protein 34; interferon-responsive finger protein 1; RING finger protein 21 (TRIM34, IFP1, RNF21)
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Structure
- belongs to the TRIM/RBCC family
- contains 1 B box-type Zn+2 finger
- contains 1 B30.2/SPRY domain
- contains 1 RING-type Zn+2 finger
Alternative splicing
named isoforms=2
Expression
- isoform 1 is the most abundant form
- highly expressed in the placenta, spleen, colon & peripheral blood leukocytes
- isoform 1 is up-regulated by interferons