tripartite motif-containing protein 8; RING finger protein 27; glioblastoma-expressed RING finger protein (TRIM8, GERP, RNF27)

Function

• interacts with SOCS1 (putative)

Structure

• homodimer
• the coiled coil domain is required for homodimerization
• belongs to the TRIM/RBCC family
• contains 2 B box-type Zn+2 fingers
• contains 1 RING-type Zn+2 finger

Expression

widely expressed

Pathology

• the name would suggest expressed in glioblastoma, but then it is widely expressed

More general terms

• tripartite motif-containing protein (trim protein)

Additional terms

• glioblastoma multiforme (GBM) or astrocytoma grade IV

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81603
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81603
• OMIM: https://mirror.omim.org/entry/606125
• UniProt: http://www.uniprot.org/uniprot/Q9BZR9.html