tripartite motif-containing protein 7; glycogenin-interacting protein; RING finger protein 90 (TRIM7, GNIP, RNF90)

Function

• forms homodimers & heterodimers
• interacts with GYG & DES

Structure

• the B30.2 domain mediates interaction with GYG
• the coiled-coil region mediates homodimerization & heterodimerization
• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 B30.2/SPRY domain
• contains 1 RING-type Zn+2 finger

Alternative splicing

named isoforms=4

Expression

• expressed in skeletal muscle & placenta
• expressed at lower levels in heart, brain & pancreas
• isoform 1 is widely expressed with high level in testis, kidney & heart

More general terms

• tripartite motif-containing protein (trim protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81786
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81786
• OMIM: https://mirror.omim.org/entry/609315
• UniProt: http://www.uniprot.org/uniprot/Q9C029.html