ATP-dependent RNA helicase DDX25; DEAD box protein 25; gonadotropin-regulated testicular RNA helicase (DDX25, GRTH)

Function

• ATP-dependent RNA helicase
• required for mRNA export & translation regulation during spermatid development
• phosphorylated on Thr
• phosphorylated form is found in the cytoplasm but not in the nucleus (putative)

Structure

• belongs to the DEAD box helicase family
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

• cytoplasm, nucleus (putative)
• detected in both cytoplasm & nucleus of testicular cells
• also detected in chromatoid bodies of round spermatids

Alternative initiation

named isoforms=2

Expression

• highly expressed in the Leydig & germ cells of the testis
• weakly expressed in pituitary & hypothalamus
• up-regulated at transcriptional level by chorionic gonadotropin

More general terms

• DEAD box ATP-dependent helicase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29118
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29118
• OMIM: https://mirror.omim.org/entry/607663
• UniProt: http://www.uniprot.org/uniprot/Q9UHL0.html