acyl-coenzyme A thioesterase 11 (acyl-CoA thioesterase 11, acyl-CoA thioester hydrolase 11, brown fat-inducible thioesterase, BFIT, adipose-associated thioesterase, ACOT11, BFIT, KIAA0707, THEA)

Function

• acyl-CoA thioesterase activity towards medium (C12) & long-chain (C18) fatty acyl-CoA substrates

Structure

• contains 2 acyl coenzyme A hydrolase domains
• contains 1 START domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung, brain
• isoform 2 is predominantly expressed in kidney, uterus, hibernoma, white adipose tissue
• induced by cold exposure, repressed by heat exposure

More general terms

• acyl-coenzyme A thioesterase

Database

• OMIM: https://mirror.omim.org/entry/606803
• UniProt: http://www.uniprot.org/uniprot/Q8WXI4.html