uridine-cytidine kinase 1; UCK 1; cytidine monophosphokinase 1; uridine monophosphokinase 1 (UCK1, URK1)

Function

• phosphorylates uridine & cytidine to uridine monophosphate & cytidine monophosphate
• does not phosphorylate deoxyribonucleosides or purine ribonucleosides
• can use ATP or GTP as a phosphate donor
• can also phosphorylate cytidine & uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, & N(4)-anisoylcytidine
• pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
• pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1

ATP + uridine = ADP + UMP

ATP + cytidine = ADP + CMP

Structure

belongs to the uridine kinase family

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• uridine-cytidine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83549
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83549
• OMIM: https://mirror.omim.org/entry/609328
• UniProt: http://www.uniprot.org/uniprot/Q9HA47.html