ribose-phosphate pyrophosphokinase 3; phosphoribosyl pyrophosphate synthase 1-like 1; PRPS1-like 1; phosphoribosyl pyrophosphate synthase 3; PRS-3 (PRPS1L1, PRPS3, PRPSL)

Function

• catalyzes synthesis of phosphoribosylpyrophosphate (PRPP), essential for nucleotide synthesis
• activated by Mg+2 & inorganic phosphate
• metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate

Cofactor: Mg+2

Structure

• homodimer
• the active form is probably an hexamer composed of 3 homodimers (putative)
• belongs to the ribose-phosphate pyrophosphokinase family

Expression

testis

Notes

• transcription may initiate from a non-AUG codon

More general terms

• phosphoribosyl pyrophosphate synthetase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=221823
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:221823
• OMIM: https://mirror.omim.org/entry/611566
• UniProt: http://www.uniprot.org/uniprot/P21108.html