diacylglycerol kinase epsilon; DAG kinase epsilon; diglyceride kinase epsilon; DGK-epsilon (DGKE, DAGK5)

Function

• highly selective for arachidonate-containing species of diacylglycerol (DAG)
• may terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition

ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• belongs to the eukaryotic diacylglycerol kinase family
• contains 1 DAGKc domain
• contains 2 phorbol-ester/DAG-type Zn+2 fingers

Compartment

membrane (potential)

Expression

expressed predominantly in testis

More general terms

• diacylglycerol kinase
• zinc finger protein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8526
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8526
• OMIM: https://mirror.omim.org/entry/601440
• UniProt: http://www.uniprot.org/uniprot/P52429.html