diacylglycerol kinase gamma; DAG kinase gamma; diglyceride kinase gamma; DGK-gamma (DGKG DAGK3)

Function

• reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid
• requires phosphatidylserine for maximal activity

ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• belongs to the eukaryotic diacylglycerol kinase family
• contains 1 DAGKc domain
• contains 2 EF-hand domains
• contains 2 phorbol-ester/DAG-type Zn+2 fingers

Compartment

• cytoplasm, membrane
• can be loosely bound to the membranes

Alternative splicing

• named isoforms=3
• at least one isoform may be inactive

Expression

• predominantly expressed in retina
• expressed at much lower level in the brain
• other tissues contain extremely low levels of DGK-gamma

More general terms

• diacylglycerol kinase
• zinc finger protein
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1608
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1608
• OMIM: https://mirror.omim.org/entry/601854
• UniProt: http://www.uniprot.org/uniprot/P49619.html