arylamine N-acetyltransferase, polymorphic; arylamine N-acetyltransferase-2 (NAT2, AAC2, PNAT)

Function

• role in the detoxification of a plethora of hydrazine & arylamine drugs
• catalyzes the N- or O-acetylation of various arylamine & heterocyclic amine substrates & is able to bioactivate several known carcinogens

acetyl-CoA + an arylamine <--> CoA + an N-acetylarylamine

Structure

belongs to the arylamine N-acetyltransferase family

Compartment

cytoplasm

Pathology

• N-acetylation polymorphism is determined by a low or high NAT activity in liver, it has been implicated in the action & toxicity of amine-containing drugs, & in the susceptibility to bladder cancer & systemic lupus erythematosus

More general terms

• arylamine N-acetyltransferase (NAT)

Database

• UniProt: http://www.uniprot.org/uniprot/P11245.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10
• OMIM: https://mirror.omim.org/entry/243400
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10