cerebroside synthase; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; ceramide UDP-galactosyltransferase (UGT8, CGT, UGT4)

Function

• catalyzes transfer of galactose to ceramide, a key enzymatic step in biosynthesis of galactocerebrosides
• sphingolipid metabolism; galactosylceramide biosynthesis

UDP-galactose + 2-(2-hydroxyacyl)sphingosine
             <-->
UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine

Structure

belongs to the UDP-glycosyltransferase family

Compartment

membrane (probably)

More general terms

• galactosyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7368
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7368
• OMIM: https://mirror.omim.org/entry/601291
• UniProt: http://www.uniprot.org/uniprot/Q16880.html