UDP-glucuronosyltransferase 2B28; UDPGT 2B28 (UGT2B28)

Function

• role in conjugation & subsequent elimination of endogenous compounds & potentially toxic xenobiotics
• glucuronidation of steroids
  • 5-beta-androstane 3-alpha,17-beta-diol
  • estradiol
  • ADT
  • eugenol
  • bile acids

Structure

belongs to the UDP-glycosyltransferase family

Compartment

• microsome, endoplasmic reticulum membrane
• single-pass membrane protein

Alternative splicing

• named isoforms=3;
• only isoform 1 active

Expression

expressed in the liver, breast, kidney

More general terms

• UDP-glucuronosyltransferase-2B (UDPGT-2B)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54490
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54490
• OMIM: https://mirror.omim.org/entry/606497
• UniProt: http://www.uniprot.org/uniprot/Q9BY64.html