N-acylneuraminate-9-phosphatase (neu5Ac-9-Pase, Haloacid dehalogenase-like hydrolase domain-containing protein 4) (NANP C20orf147 HDHD4)

Function

• carbohydrate metabolism; aminosugar metabolism

N-acylneuraminate 9-phosphate + H2O
                 <-->
N-acylneuraminate + phosphate

Cofactor: Mg+2

Inhibition:

• inhibited by vanadate & Ca+2

Kinetic parameters:

• KM=0.09 mM for N-acetylneuraminate 9-P
• Vmax=112 umol/min/mg enzyme with N-acetylneuraminate 9-P as substrate

Structure

• belongs to the haloacid dehalogenase-like hydrolase superfamily, NANP family

More general terms

• phosphomonoesterase

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TBE9.html