eukaryotic peptide chain release factor GTP-binding subunit ERF3B (eukaryotic peptide chain release factor subunit 3b, eRF3b, G1 to S phase transition protein 2 homolog, GSPT2, ERF3B)

Function

• may play a role in translation termination & in cell cycle progression
• may play a role as a potent stimulator of the release factor activity of ETF1
• exhibits GTPase activity, which is ribosome- & ETF1-dependent
• interacts with ETF1 (putative)

Structure

• belongs to the GTP-binding elongation factor family ERF3 subfamily

Compartment

cytoplasm (probable)

Pathology

highly expressed in IUCC stage II colorectal cancer

More general terms

• guanosine triphosphatase (GTPase)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2370
• OMIM: https://mirror.omim.org/entry/300418
• UniProt: http://www.uniprot.org/uniprot/Q8IYD1.html