chromosomal translocation t2q13:3p25 (follicular thyroid carcinoma)

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Introduction

t(2;3)(q13;p25) identified in a subset of thyroid follicular carcinomas results in fusion of PAX8 to PPAR-gamma1 genes. PAX8-PPARG1 fusion protein inhibited thiazolidinedione induced transactivation by PPAR-gamma1 in a dominant negative manner.

More general terms

Additional terms

References

  1. ↑ Kroll et al. Science 289:1357-60, 2000
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