myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2v; MLC-2 (MYL2)

Function

• myosin regulatory light chain
• binds Ca+2

Structure

contains 3 EF-hand domains

Pathology

• defects in MYL2 are the cause of:
  • familial hypertrophic cardiomyopathy type 10
  • hypertrophic cardiomyopathy with mid-LV chamber-2

More general terms

• myosin regulatory light chain (MRLC)

Additional terms

• myosin

Database

• UniProt: http://www.uniprot.org/uniprot/P10916.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4633
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4633
• OMIM: https://mirror.omim.org/entry/160781
• OMIM: https://mirror.omim.org/entry/608758