myosin regulatory light chain MRLC3; myosin regulatory light chain 2, nonsarcomeric; myosin RLC; MLC-2B (MRLC3, MLCB, MYL12A, RLC)

Function

• myosin regulatory light chain
• role in regulation of both smooth muscle & nonmuscle cell contractile activity via its phosphorylation
• implicated in cytokinesis, receptor capping, & cell locomotion (putative)
• binds Ca+2
• phosphorylation increases the actin-activated myosin ATPase activity, thus regulates the contractile activity
• required to generate the driving force in the migration of cells, but not necessary for localization of myosin-2 at the leading edge (putative)

Structure

contains 3 EF-hand domains

More general terms

• myosin regulatory light chain (MRLC)

Additional terms

• myosin

Database

• UniProt: http://www.uniprot.org/uniprot/P19105.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10627
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10627
• OMIM: https://mirror.omim.org/entry/609211