myosin light chain 3; myosin light chain 1, slow-twitch muscle B/ventricular isoform; MLC1SB; ventricular/slow twitch myosin alkali light chain; cardiac myosin light chain-1; CMLC1 (MYL3)

Function

• myosin essential light chain
• does not bind Ca+2

Structure

• the N-terminus is blocked
• contains 3 EF-hand domains

Pathology

• defects in MYL3 are the cause of:
  • familial hypertrophic cardiomyopathy type 8
  • hypertrophic cardiomyopathy with mid-LV chamber-1

More general terms

• myosin essential (alkali) light chain

Additional terms

• myosin

Database

• UniProt: http://www.uniprot.org/uniprot/P08590.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4634
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4634
• OMIM: https://mirror.omim.org/entry/160790
• OMIM: https://mirror.omim.org/entry/608751