troponin C, skeletal muscle (TNNC2)

Function

• troponin is the central regulatory protein of striated muscle contraction
• it consists of three components:
  • troponin-I, the inhibitor of actomyosin ATPase
  • troponin-T contains the binding site for tropomyosin
  • troponin-C
• binding of Ca+2 to troponin-C abolishes the inhibitory action of troponin on actin filaments
• skeletal muscle troponin C binds four Ca+2

Structure

• belongs to the troponin C family
• contains 4 EF-hand domains

More general terms

• troponin-C

Database

• UniProt: http://www.uniprot.org/uniprot/P02585.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7125
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7125
• OMIM: https://mirror.omim.org/entry/191039