silent brain infarct

^[1]^[2]^[3]

Epidemiology

28% of individuals, mean age of 75 years

nearly twice as likely to develop symptomatic stroke than those without infarcts (7.3% vs 3.8% within 4 years)^[1]
multiple silent infarcts further increase risk of symptomatic stroke (9.6% for multiple vs 5.9% for single silent infarct)^[1]
2-3 fold risk of ischemic stroke within 15 years^[2]
associated with cognitive dysfunction^[3]

↑ ^1.0 ^1.1 ^1.2 Journal Watch 21(22):178, 2001
Bernick C, Kuller L, Dulberg C et al Silent MRI infarcts and the risk of future stroke: the cardiovascular health study. Neurology. 2001 Oct 9;57(7):1222-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11591840
↑ ^2.0 ^2.1 Orciari Herman A, Hefner JE Silent Brain Infarction Associated with Increased Risk for Future Stroke. Physician's First Watch, Feb 18, 2016 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
Gupta A, Giambrone AE, Gialdini G et al Silent Brain Infarction and Risk of Future Stroke. A Systematic Review and Meta-Analysis. Stroke. Feb 17, 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26888534 <Internet> http://stroke.ahajournals.org/content/early/2016/02/17/STROKEAHA.115.011889
↑ ^3.0 ^3.1 Anand SS, Friedrich MG, Desai D et al. Reduced cognitive assessment scores among individuals with magnetic resonance imaging-detected vascular brain injury. Stroke 2020 Apr; 51:1158. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32126938 https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.028179