cholesterol LDL in serum calculated

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Introduction

LDL-cholesterol is generally calculated from measurements of total cholesterol, HDL-cholesterol & triglycerides & the assumption that the VLDL-cholesterol is equal to 1/5 of the triglyceride concentration, using the formula:

[LDL-chol] = [total chol] - [HDL-chol] - [[[A18141|triglycerides]]/5]

This equation works well for triglycerides < 400 mg/dL in the absence of dysbetalipoproteinemia.

see cholesterol LDL in serum

↑ Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993, pg 1055-56
↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
↑ Prescriber's Letter 11(8): 2004 New National Cholesterol Education Program (NCEP) Recommendations Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200801&pb=PRL (subscription needed) http://www.prescribersletter.com
↑ Wiviott SD, Cannon CP, Morrow DA, Ray KK, Pfeffer MA, Braunwald E; PROVE IT-TIMI 22 Investigators. Can low-density lipoprotein be too low? The safety and efficacy of achieving very low low-density lipoprotein with intensive statin therapy: a PROVE IT-TIMI 22 substudy. J Am Coll Cardiol. 2005 Oct 18;46(8):1411-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16226163
↑ Hayward RA, Hofer TP, Vijan S. Narrative review: lack of evidence for recommended low-density lipoprotein treatment targets: a solvable problem. Ann Intern Med. 2006 Oct 3;145(7):520-30. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17015870