cafe au lait spots

Introduction

Pigmented cutaneous lesions.

Etiology

• neurofibromatosis type 1 (von-Recklinghausen's disease)
• Bloom's syndrome
• McCune-Albright syndrome
• Fanconi anemia
• multiple endocrine neoplasia [MEN] type 2B
• Nijmegen breakage syndrome
• Turcot syndrome

Pathology

• excess of melanosomes in malphigian cells

Clinical manifestations

• color: light to dark brown

More general terms

• pigmentation disorder