Gleason scoring system for prostate cancer
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Introduction
Grading ranges from:
1 (more differentiated) to 5 (less differentiated)
More than 1 pattern may be present in a surgical specimen. The 2 predominant histological patterns are graded individually, then added for a final Gleason score. For example, 3 + 4 = 7.
Thus, the scores range from 2-10.
Grades: (individual histopathology patterns)[3]
- small uniform cells
- more space between cells
- infiltration of cells from glands at margins
- irregular masses of cells with few glands
- lack of glands, sheets of cells
Gleason score:
- 2-6: low grade or well-differentiated tumor
- 7: moderate-grade or moderately differentiated tumor
- 8-10: high-grade or poorly differentiated tumor
Final grades 2-6 are associated with a better prognosis.
15 year mortality from prostate cancer by Gleason score
| Gleason score | 15 year mortality |
|---|---|
| 2-5 | 4-11% |
| 6 | 20-30% |
| 7 | 40-70% |
| 8-10 | 60-90% |
More general terms
References
- ↑ Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 675
- ↑ Aronson WJ, in: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- ↑ 3.0 3.1 Quiz: Do You Know the Current Guidelines for the Screening and Treatment of Prostate Cancer? Medscape. Jul 24, 2014