1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1; phospholipase C-zeta-1; PLC-zeta-1; testis-development protein NYD-SP27 (PLCZ1)
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Function
- in vitro, hydrolyzes Ptdins(4,5)P2 (Ca+2-dependent)
- triggers intracellular Ca+2 oscillations in oocytes solely during M phase
- involved in inducing oocyte activation & initiating embryonic development up to the blastocyst stage
- candidate egg-activating soluble sperm factor transferred from sperm into the egg cytoplasm following gamete membrane fusion
- may exert an inhibitory effect on phospholipase-C-coupled processes that depend on Ca+2 & protein kinase C, including CFTR trafficking & function
- interacts via its C2 domain with Ptdins(3)P &, to a lesser extent, Ptdins(5)P in vitro (putative)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O <--> 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Structure
- the EF-hand & C2 domains are essential for triggering Ca+2 oscillating activity & the regulation of PLCZ1 enzyme activity (putative)
- the X-Y linker region between PI-PLC X-box & Y-box domains may be a target for proteolysis & may play an important regulatory role during fertilization (putative)
- contains 1 C2 domain
- contains 1 EF-hand domain
- contains 1 PI-PLC X-box domain
- contains 1 PI-PLC Y-box domain
Compartment
- nucleus (putative), cytoplasm, perinuclear region (putative)
- exhibits alternative cytoplasmic/nuclear localization during development
- translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis & localizes again to the pronucleus at interphase following meiosis & mitosis (putative)
Alternative splicing
named isoforms=3
Expression
- expressed specifically in testis
- weakly expressed in pancreatic-duct cells
Pathology
- up-regulated in pancreatic-duct cells from patients with cystic fibrosis