1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-acylglycerol-3-phosphate O-acyltransferase 2; 1-AGP acyltransferase 2; 1-AGPAT 2; lysophosphatidic acid acyltransferase beta; LPAAT-beta (AGPAT2)

Function

• converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone
• phospholipid metabolism; CDP-diacylglycerol biosynthesis

CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3

acyl-CoA + 1-acyl-sn-glycerol 3-phosphate =

CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• the HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (putative)
• belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

Compartment

membrane (putative)

Alternative splicing

named isoforms=2

Expression

expressed predominantly in heart & liver

Pathology

• defects in AGPAT2 are the cause of Berardinelli-Seip congenital lipodystrophy type 1

More general terms

• 1-acyl-sn-glycerol-3-phosphate acyltransferase
• transmembrane 3 protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10555
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10555
• OMIM: https://mirror.omim.org/entry/603100
• OMIM: https://mirror.omim.org/entry/608594
• UniProt: http://www.uniprot.org/uniprot/O15120.html