1-acyl-sn-glycerol-3-phosphate acyltransferase theta; lysophosphatidic acid acyltransferase theta; LPAAT-theta; acyl-CoA:glycerol-3-phosphate acyltransferase 3; hGPAT3; lung cancer metastasis-associated protein 1; MAG-1 (AGPAT9, GPAT3, MAG1, HMFN0839, UNQ2753/PRO6492)
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Function
- catalyzes 1st step during de novo synthesis of triacylglycerol
- converts lysophosphatidic acid into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone
- overexpression activates the mTOR pathway
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
<-->
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
Inhibition:
- inhibited by N-ethylmaleimide (NEM)
Structure
- belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
- HXXXXD motif
- essential for acyltransferase activity
- may constitute binding site for phosphate moiety of glycerol-3-phosphate
Compartment
endoplasmic reticulum membrane
Expression
- widely expressed
- expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus, placenta
- expressed lung & adipose tissue