1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; 1-acylglycerol-3-phosphate O-acyltransferase 5; 1-AGP acyltransferase 5; 1-AGPAT 5; lysophosphatidic acid acyltransferase epsilon; LPAAT-epsilon (AGPAT5)

Function

• converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (putative)
• phospholipid metabolism; CDP-diacylglycerol biosynthesis
• CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3

acyl-CoA + 1-acyl-sn-glycerol 3-phosphate =

CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• the HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (putative)
• belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

Compartment

membrane (putative)

Notes

• uncertain whether Met-1 or Met-12 is the initiator

More general terms

• 1-acyl-sn-glycerol-3-phosphate acyltransferase
• transmembrane 3 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55326
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55326
• UniProt: http://www.uniprot.org/uniprot/Q9NUQ2.html