lysozyme-C; 1,4-beta N-acetylmuramidase C (LYZ, LZM)

Function

• lysozymes have primarily a bacteriolytic function
• lysozymes in tissues & body fluids are associated with the monocyte-macrophage system
• lysozymes hydrolyze of (1->4)-beta-linkages between N-acetylmuramic acid & N-acetyl-D-glucosamine residues in a peptidoglycan & between N-acetyl-D-glucosamine residues in chitodextrins
• lysozyme C is capable of both hydrolysis & transglycosylation
• slight esterase activity
• acts rapidly on both peptide-substituted & unsubstituted peptidoglycan, & slowly on chitin oligosaccharides

Structure

• monomer
• belongs to the glycosyl hydrolase 22 family

Pathology

• defects in LYZ are a cause of amyloidosis type 8

More general terms

• muramidase or lysozyme

Database

• UniProt: http://www.uniprot.org/uniprot/P61626.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4069
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4069
• OMIM: https://mirror.omim.org/entry/105200
• OMIM: https://mirror.omim.org/entry/153450