2'-5'-oligoadenylate synthase 1; (2-5')oligo(A) synthase 1; 2-5A synthase 1; E18/E16; p46/p42 OAS (OAS1, OIAS)

Function

• may play a role in mediating resistance to virus infection, control of cell growth, differentiation, & apoptosis
• binds double-stranded RNA & polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent Rnase-L that, when activated, cleaves single-stranded RNAs

Structure

• homotetramer
  • belongs to the 2-5A synthase family

Compartment

• mitochondria, nucleus, microsome, endoplasmic reticulum
• associated with different subcellular fractions such as mitochondrial, nuclear, & rough/smooth microsomal fractions

Alternative splicing

• named isoforms=4
• p46 = 46 kD, E18
• p41 = 41 kD, E16, 3-9
• p48 = 9-2

Expression

induced by interferons

More general terms

• 2'5'-oligoadenylate synthetase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4938
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4938
• OMIM: https://mirror.omim.org/entry/164350
• UniProt: http://www.uniprot.org/uniprot/P00973.html