fibrinogen in plasma
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Indications
- evaluation of disseminated intravascular coagulation
- evaluation of inflammation (confirmation of elevated ESR)
Reference interval
Clinical significance
- fibrinogen is an acute phase protein
- increased plasma levels are an independent risk factor for coronary artery disease & cerebrovascular disease
- fibrinogen is the principal plasma protein affecting the erythrocyte sedimentation rate (ESR)
Increases
- inflammation (within 24 hours)
- tissue necrosis
- estrogens & oral contraceptives
Decreases
- decreased hepatic synthesis
- disseminated intravascular coagulation (DIC)
- anabolic steroids & androgens
- fish oil
- plasminogen activators
- valproic acid
- afibrinogenemia (rare)
Methods
- thrombin clotting time of dilute plasma
- radioimmunodiffusion (RID)
- total fibrinogen, measured by immunoassay may not correlate with functional fibrinogen in patients with dysfibrinogenemia
Specimen
More general terms
More specific terms
Additional terms
Component of
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995
- ↑ Fibrinogen Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030130.jsp
- ↑ Panel of 3 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030137.jsp
- ↑ Panel of 7 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0000000.jsp