fibromyalgia syndrome (fibromyositis, fibrositis)

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Introduction

* also see chronic fatigue syndrome/myalgic encephalomyelitis

Etiology

Epidemiology

  • 4-11% of population; 2% of U.S. population >= 18 years[32]
  • more common in women (3.4%) than men (0.5%)[32]
  • typically presents in middle-age women, but onset of pain often occurs earlier in life

Pathology

Genetics

Clinical manifestations

Diagnostic criteria

  • widespread pain* present for >= 3 months
  • no other diagnosis to explain symptoms[32]

* Widespread pain index & symptom severity scale[32]

Laboratory

* questionable[14]

* 9,3% of patients with fibromylagia found to have consistently low serum alkaline phosphatase levels consistent with hypophosphatasia[48]

Diagnostic procedures

Complications

Differential diagnosis

Management

Comparative biology

  • infusion of IgG from fibromyalgia patients into mice caused fibromyalgia-like symptoms in the mice[44]
    • fibromyalgia-like symptoms in the mice were attentuated when IgG infusions were stopped

Notes

More general terms

More specific terms

Additional terms

References

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Patient information

fibromylagia syndrome patient information