non-steroidal anti-inflammatory agent (NSAID)

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Introduction

An aspirin-like drug that reduces pain & inflammation arising from injured tissue through inhibition of prostaglandin synthesis.

Indications

Contraindications

Cautions:

Dosage

(administration)

Pharmacokinetics

Monitor

Adverse effects

* NSAIDS may increase salt & water retention

* 10 days of NSAID therapy prior to interstitial nephritis[42]

Overdose:

Risk factors for adverse effects[3]

Drug interactions

Laboratory

Mechanism of action

More general terms

More specific terms

Additional terms

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 792
  2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 14, 598, 853
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  4. Prescriber's Letter 8(3):14 2001
  5. 5.0 5.1 5.2 Prescriber's Letter 9(5):29 2002
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    Peura DA Mandate to modify a medicinal mantra: maybe not yet? Gastroenterology 124:842, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12612918
  7. Prescriber's Letter 10(10):58 2003
  8. 8.0 8.1 8.2 Journal Watch 24(14):109, 2004 Mamdani M, Juurlink DN, Lee DS, Rochon PA, Kopp A, Naglie G, Austin PC, Laupacis A, Stukel TA. Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study. Lancet. 2004 May 29;363(9423):1751-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15172772
  9. Prescriber's Letter 12(2): 2005 Update on the Safety and Use of COX-2 Inhibitors and Traditional NSAIDs Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210202&pb=PRL (subscription needed) http://www.prescribersletter.com
  10. Prescriber's Letter 12(5): 2005 FDA Announces Important Changes and Additional Warnings for COX-2s and NSAIDs Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210505&pb=PRL (subscription needed) http://www.prescribersletter.com
  11. FDA MedWatch COX-2 Selective (includes Bextra, Celebrex, and Vioxx) and Non-Selective Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) http://www.fda.gov/medwatch/SAFETY/2005/safety05.htm#NSAID
  12. 12.0 12.1 Journal Watch 25(13):102, 2005 Maiden L, Thjodleifsson B, Theodors A, Gonzalez J, Bjarnason I. A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. Gastroenterology. 2005 May;128(5):1172-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15887101
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  14. 14.0 14.1 Journal Watch 25(16):126, 2005
    Hippisley-Cox J, Coupland C. Risk of myocardial infarction in patients taking cyclo- oxygenase-2 inhibitors or conventional non-steroidal anti- inflammatory drugs: population based nested case-control analysis. BMJ. 2005 Jun 11;330(7504):1366. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15947398 <Internet> http://bmj.bmjjournals.com/cgi/content/full/330/7504/1366
  15. Prescriber's Letter 12(9): 2005 Non-narcotic Analgesics and the Risk of Hypertension in Women Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210915&pb=PRL (subscription needed) http://www.prescribersletter.com
  16. 16.0 16.1 16.2 Gislason GH et al Increased mortality and cardiovascular morbidity associated with the use of nonsteroidal anti-inflammatory drugs in chronic heart failure. Arch Intern Med 2009 Jan 26; 169:141. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19171810
  17. 17.0 17.1 Rostom A et al. Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: Benefits versus risks. Aliment Pharmacol Ther 2009 Mar 1; 29:481. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19053986
  18. 18.0 18.1 Prescriber's Letter 17(8): 2010 Managing NSAID Risks Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260810&pb=PRL (subscription needed) http://www.prescribersletter.com
  19. 19.0 19.1 19.2 Prescriber's Letter 18(12): 2011 NSAIDs and Hypertension Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=271224&pb=PRL (subscription needed) http://www.prescribersletter.com
  20. Johannesdottir SA et al Nonsteroidal anti-inflammatory drugs and the risk of skin cancer Cancer, May 29, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22644960 <Internet> http://onlinelibrary.wiley.com/doi/10.1002/cncr.27406/abstract
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  23. 23.0 23.1 Prescriber's Letter 21(3): 2014 NSAID Safety in Patients with Heart Disease Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=300322&pb=PRL (subscription needed) http://www.prescribersletter.com
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    Laine L. NSAID-associated gastrointestinal bleeding: Assessing the role of concomitant medications. Gastroenterology 2014 Oct; 147:730. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25167988
  26. 26.0 26.1 FDA Drug Safety Alert. July 9, 2014 Non-aspirin Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Drug Safety Communication - FDA Strengthens Warning of Increased Chance of Heart Attack or Stroke http://www.fda.gov/Drugs/DrugSafety/ucm451800.htm http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm454141.htm
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  38. 38.0 38.1 FDA MedWatch. Oct 15, 2020 Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Drug Safety Communication
    Avoid Use of NSAIDs in Pregnancy at 20 Weeks or Later. https://www.fda.gov/safety/medical-product-safety-information/nonsteroidal-anti-inflammatory-drugs-nsaids-drug-safety-communication-avoid-use-nsaids-pregnancy-20
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  45. Symptoms & Causes of Peptic Ulcers (Stomach Ulcers) https://www.niddk.nih.gov/health-information/digestive-diseases/peptic-ulcers-stomach-ulcers/symptoms-causes

Patient information

non-steroidal anti-inflammatory agent patient information