group XV phospholipase A2; 1-O-acylceramide synthase; ACS; LCAT-like lysophospholipase; LLPL; lysophospholipase 3; lysosomal phospholipase A2; phospholipase A2 group 15; LPLA2 (PLA2G15 LYPLA3 UNQ341/PRO540)

Function

• transacylase & Ca+2-independent phospholipase A2 activity
• catalyzes the formation of 1-O-acyl-N-acetylsphingosine & concomitant release of a lysophospholipid
• may have weak lysophospholipase activity

Structure

• N-glycosylated
• belongs to the AB hydrolase superfamily, lipase family

Compartment

lysosome, secreted

Expression

• expressed in heart, placenta, skeletal muscle, kidney, pancreas > spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes

Pathology

• biomarker of brain aging (positive correlation)

More general terms

• transferase
• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23659
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23659
• OMIM: https://mirror.omim.org/entry/609362
• UniProt: http://www.uniprot.org/uniprot/Q8NCC3.html