11-beta hydroxysteroid dehydrogenase-1 (corticosteroid 11-beta-dehydrogenase isozyme 1, 11-DH, 11-beta-HSD1, HSD11B1, HSD11, HSD11L)

Function

• catalyzes reversibly conversion of cortisol to inactive metabolite cortisone
• catalyzes conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol; in intact cells, reaction runs only in one direction (putative)

11-beta-hydroxysteroid + NADP+ <-->  11-oxosteroid + NADPH

Structure

• homodimer (putative)
• glycosylated
• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

• endoplasmic reticulum membrane

Expression

• widely expressed
• ighest expression in liver

Pathology

• defects in HSD11B1 are a cause of cortisone reductase deficiency

More general terms

• 11-OH steroid dehydrogenase; corticosteroid 11-beta dehydrogenase
• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/600713
• OMIM: https://mirror.omim.org/entry/604931
• UniProt: http://www.uniprot.org/uniprot/P28845.html