nicotinamide mononucleotide

^[1]^[2]

Indications

product of nicotinamide phosphoribosyltransferase
- increases in vivo levels of NAD^[2]
activates SIRT1 activity^[1]
increases capillary density & blood flow in skeletal muscle of old mice via activation of SIRT1
NMN mimics & augments exercise by inhibiting NICD-NOTCH (in mice)^[2]
increases endurance in old mice^[2]

↑ ^1.0 ^1.1 ^1.2 Imai S A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacol Res. 2010 Jul;62(1):42-7 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20085812 Free PMC Article
↑ ^2.0 ^2.1 ^2.2 ^2.3 Das A, Huang GX, Bonkowski MS et al. Impairment of an endothelial NAD+ -H2S signaling network is a reversible cause of vascular aging. Cell 2018 Mar 22; 173:74-89 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29570999 <Internet> http://www.cell.com/cell/fulltext/S0092-8674(18)30152-1