myasthenia gravis

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Etiology

Epidemiology

  • occurs most common in women 20-30 years & men > age 50 years[2]

Pathology

Clinical manifestations

* distinguishes from botulism

Laboratory

Diagnostic procedures

* acetylcholinesterase activity is inhibited at a lower temperature

Radiology

Complications

Differential diagnosis

Management

More general terms

More specific terms

Additional terms

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996 pg 1056-57
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 15, 16, 17, 18, 19. American College of Physicians, Philadelphia 1998, 2006, 2009, 2012, 2015, 2018, 2021.
    Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  3. 3.0 3.1 ARUP Consult: Myasthenia Gravis - MG The Physician's Guide to Laboratory Test Selection &vInterpretation https://www.arupconsult.com/content/myasthenia-gravis
    ARUP Consult: Myasthenia Gravis Testing https://arupconsult.com/ati/myasthenia-gravis-testing
  4. 4.0 4.1 4.2 The NNT: Myasthenia Gravis Diagnostics and Likelihood Ratios, Explained http://www.thennt.com/lr/myasthenia-gravis/
    Scherer K, Bedlack RS, Simel DL. Does this patient have myasthenia gravis? JAMA. 2005 Apr 20;293(15):1906-14. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15840866
  5. Kumar V1, Kaminski HJ. Treatment of myasthenia gravis. Curr Neurol Neurosci Rep. 2011 Feb;11(1):89-96. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20927659
  6. Silvestri NJ, Wolfe GI. Myasthenia gravis. Semin Neurol. 2012 Jul;32(3):215-26 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23117946
  7. 7.0 7.1 Liu WW, Chen A Diagnosing Myasthenia Gravis with an Ice Pack. N Engl J Med 2016; 375:e39. November 10, 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27959645 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1509523
  8. Gilhus NE Myasthenia Gravis N Engl J Med 2016; 375:2570-2581. December 29, 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28029925 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMra1602678
  9. 9.0 9.1 Lowes R FDA Approves Delafloxacin (Baxdela) for Skin Infections Medscape - Jun 19, 2017. http://www.medscape.com/viewarticle/881827
  10. Sanders DB, Guptill JT. Myasthenia gravis and Lambert-Eaton myasthenic syndrome. Continuum (Minneap Minn). 2014 Oct;20 (5 Peripheral Nervous System Disorders):1413-25. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2529929
  11. 11.0 11.1 11.2 11.3 11.4 11.5 Narayanaswami P et al. International consensus guidance for management of myasthenia gravis: 2020 update. Neurology 2020 Nov 3 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33144515 Review. https://n.neurology.org/content/96/3/114
  12. 12.0 12.1 Piehl F, Eriksson-Dufva A, Budzianowska A et al Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis. The RINOMAX Randomized Clinical Trial. JAMA Neurol. 2022;79(11):1105-1112 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36121672 PMCID: PMC9486640 Free PMC article https://jamanetwork.com/journals/jamaneurology/fullarticle/2796552
  13. 13.0 13.1 NEJM Knowledge+
    Alhaidar MK, Abumurad S, Soliven B, Rezania K Current Treatment of Myasthenia Gravis. J Clin Med. 2022 Mar 14;11(6):1597. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35329925 PMCID: PMC8950430 Free PMC article. Review.
  14. Narayanaswami P, Sanders DB, Thomas L et al. Comparative effectiveness of azathioprine and mycophenolate mofetil for myasthenia gravis (PROMISE-MG): A prospective cohort study. Lancet Neurol 2024 Mar; 23:267-276. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38365379 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00028-0/abstract
  15. National Institute of Neurological Disorders and Stroke (NINDS)
    NINDS Myasthenia Gravis Information Page https://www.ninds.nih.gov/Disorders/All-Disorders/Myasthenia-Gravis-Information-Page
    Myasthenia Gravis Fact Sheet https://www.ninds.nih.gov/disorders/patient-caregiver-education/fact-sheets/myasthenia-gravis-fact-sheet

Patient information

myasthenia gravis patient information

Database