spectinomycin (Trobicin, Actinospectacin)

Introduction

Tradename: Trobicin. (spectinomycin hydrochloride)

Indications

• urogenital infection
  • treatment of uncomplicated gonorrhea
• proctitis

Dosage

• gonorrhea:
  • 40 mg/kg up to 2 g IM single dose
  • 4 g (2 different sites of injection) may be used where antibiotic resistance is prevalent

Powder for injection: 2 g, 4 g.

Antimicrobial activity

• Neisseria gonorrhoeae

Adverse effects

• uncommon (< 1%)
  • dizziness, headache, urticaria, rash, pruritus, nausea/vomiting, pain at site of injection, chills

• drug adverse effects of aminoglycosides

More general terms

• heterocyclic compound, 3 rings
• ether
• aminoglycoside antibiotic

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15541
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=64771
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2021
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3033928
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=64769
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=64740