baclofen (Lioresal)

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Introduction

Tradename: Lioresal.

Indications

Contraindications

Caution: elderly patients are sensitive to bacolfen

pregnancy category = c

safety in lactation = ?

Dosage

Start 5 mg PO TID, max 80 mg/day

Tabs: 10 & 20 mg.

Dosage adjustment in renal failure

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. 2.0 2.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. 4.0 4.1 Medications Can Cause Seizures Prescriber's Letter 10(3):16 2003 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=190320&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. 5.0 5.1 Omari TI et al, Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease. A randomized controlled trial. J Pediatr 2006, 149:468 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17011315
    Di Lorenzo C Gastroesophageal reflux. Not a time to relax. J Pediatr 2006, 149:436 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17011308
  6. 6.0 6.1 Prescriber's Letter 15(12): 2008 Common Oral Medications that May Need Tapering Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=241208&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. Deprecated Reference
  8. 8.0 8.1 Muanda FT, Weir MA, Bathini L et al. Association of baclofen with encephalopathy in patients with chronic kidney disease. JAMA 2019 Nov 9; PMID: https://www.ncbi.nlm.nih.gov/pubmed/31705755
    Chauvin KJ, Blake PG, Garg AX et al. Baclofen has a risk of encephalopathy in older adults receiving dialysis. Kidney Int. 2020;98(4):979-988 PMID: https://www.ncbi.nlm.nih.gov/pubmed/32450156 https://www.kidney-international.org/article/S0085-2538(20)30552-4/fulltext
    Wolf E, Kothari NR, Roberts JK et al. Baclofen toxicity in kidney disease. Am J Kidney Dis. 2018;71(2):275-280 PMID: https://www.ncbi.nlm.nih.gov/pubmed/28899601 https://www.ajkd.org/article/S0272-6386(17)30846-6/fulltext
  9. 9.0 9.1 Su Zhang VR, Niu F, Lee EA et al Safety of baclofen versus tizanidine for older adults with musculoskeletal pain. J Am Geriatr Soc. 2023 Mar 29 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36989193
  10. 10.0 10.1 Hwang YJ, Chang, SR, Brotman DJ et al Baclofen and the Risk of Encephalopathy: A Real-World, Active-Comparator Cohort Study. Mayo Clinic Proceedings. 2023. April 5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37028980 https://www.mayoclinicproceedings.org/article/S0025-6196(22)00649-8/fulltext
  11. 11.0 11.1 Hwang YJ, Chang AR, Brotman DJ, Inker LA, Grams ME, Shin JI. Baclofen and the risk of fall and fracture in older adults: A real-world cohort study. J Am Geriatr Soc. 2023 Nov 7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37933734 https://agsjournals.onlinelibrary.wiley.com/doi/abs/10.1111/jgs.18665

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