phendimetrazine (Mephenmetrazine)

Introduction

DEA-controlled substance: class 3.

Dosage

• 35 mg PO before meals
• 105 mg of slow release form daily
• 17.5-105 mg QD (divided TID or QD (slow release)

Pharmacokinetics

• metabolized in liver to largely inactive metabolites
• metabolites excreted by the kidney
• 1/2 life: 5-12 hours

elimination via liver

elimination via kidney

1/2life = 5-12 hours

Adverse effects

• insomnia
• agitation
• nervousness
• hyperthermia
• hyperventilation
• hypertension
• convulsions

• drug adverse effects of analeptics
• drug adverse effects of psychotropic agents
• drug adverse effects of sympathomimetic(s)

Interferences

• may cause false positives in immunoassays for amphetamines in urine

Mechanism of action

• CNS stimulant
• appetite suppressant

More general terms

• adrenergic neuron stimulant
• analeptic (CNS stimulant)
• amine
• aromatic compound

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=12460
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=30487